It is a special day for Luì, who is finally about to receive his diploma as a scientist, and as always, Sofì is there by his side to support him and give him courage. Pongo, their loyal friend, certainly cannot miss the event. Once again, however, Mr. S and Perfidia will try to undermine the Me against You but Sofì, with the powers of a fairy, and Luì, with the best technology worthy of a true scientist, will give a hard time to their enemies. Something goes wrong and the magic will catapult everyone to distant places and times … lost in time! In this magical journey, Me Against You will discover that they have new friends and will meet a new, fierce enemy. A fantastic and exciting cinema adventure for Luì and Sofì, full of surprises and with lots of fun for their little fans and all families.